In this interview, we speak to Sir Richard Feachem, who is Professor of Global Health at both the University of California, San Francisco, and the University of California, Berkeley, and Director of the Global Health Group. Sir Feachem was also the founding Executive Director of the Global Fund to Fight AIDS, Tuberculosis and Malaria, which has saved over 4.9 million lives globally. We discuss the key issues facing health in the developed and developing world, strategies to eradicate some of the most prevalent conditions, and the future of global health.