I want you to make a fist and hold it just to the left of the centre of your chest.  Just under your ribs, is an organ, around that size, which will beat around 3 billion times in your lifetime pumping blood around the 100,000 miles of vessels that supply every part of your body. The heart is a miraculous product of evolution, and one which plays a role more critical in the fact that we are alive, and the fact that we could die – than any other organ in our body.   Perhaps unsurprising therefore that even with our advances in medical science, cardiovascular disease remains the largest single health burden to humanity, contributing to over 30% of all deaths worldwide and costing the global economy over $1 trillion each year. To understand more about the reality of cardiovascular disease, I spoke to two of the world’s most preeminent cardiovascular physicians, Dr. Haider Warraich (Author of: State of the Heart, Exploring the History, Science and Future of Cardiac Disease) and Dr. Sandeep Jauhar (Author of: Heart: A History)