In a bit of a unique proposition, this exchange was created before the ecosystem existed. When you look at the growth and development of WTI, you have Houston which has production, New York which provides financing, the refineries on the Gulf Coast, the traders, marketers, banks and many other pieces of the puzzle which are already there. The DME was a bit of a unique experiment, we created an exchange before all parts of the ecosystem were in place.

I don't think you can find any other organ in the body that has correlation with so many other organs than the mouth. Research has been widespread, and over the past 30 years, gum disease has been linked to heart disease, to colorectal cancer, to diabetes, to all sorts of issues within the body.

More girls have been killed in the past fifty years, precisely because they were girls, than men were killed in all the battles of the twentieth century.

Knowledge isn't always used to make people better off, of course. It can be used to make more lethal weaponry and more effective militia and armies – so we must couple knowledge with humanism, with universal sympathy, for it to be a force for good. Without knowledge, however, all the sympathy in the world would be impotent – they must exist together.

I guess the only thing I would say is if you get to the point to where you could comfortably believe that I could die tomorrow and I wouldn't regret my life, I think at least for me, I think that's where success would be.