I believe many of our new generation of entrepreneurs put too much significance on money, and not enough on ideas. If you have a great idea, and the skills to execute that idea, the money will come.

I define disruption as being where the incumbent players and incumbents somehow deny what their customers are saying or want differently. A disruptor comes in, sees a problem more clearly, and in some cases has more freedom to attack the problem.

To confront cancer is to encounter a parallel species, one perhaps more adapted to survival than we are. This image- of cancer as our desperate, malevolent, contemporary doppelganger- is so haunting because it is at least partly true.

Entrepreneurship is on a pedestal; everyone wants to be one. Here's the truth, it sucks. Entrepreneurship is hard and almost everyone loses. You genuinely have to like getting beat-up. You genuinely have to like conflict. You genuinely have to have an enormous amount of patience.

Entrepreneurship means a constant willingness to keep learning. It's about maintaining that start-up spirit—where you're forever young, and forever in crisis. It's about always having your mind on the business: Lying in bed and constantly asking yourself, What should I do?