In the spring, when we lose an hour of sleep, we observe a consequential 24% increase in heart attacks the following day. In the Autumn, when we gain an hour, we see a corresponding 21% reduction in heart attacks.

One you have to get a unique insight. It starts there. Two, you need to be prepared to devote a lot of energy and commitment.

the knowledge that we must die 'the worm at the core' of the human condition

When you're starting out, your ambition shouldn't be defined by someone else's success criteria. That's something I struggled with, and still do. I struggle to align my business objectives with my life and my own motivations rather than externally formed motivations that come from culture and society.

I think both examples share one glaring mistake. They overlook the fact that even though knowledge diffuses, it is also agglomerative—it tends to concentrate. When it comes to the growth of knowledge, you need to double down on the capacities you already have; you want to build on cities that possess a foundation.

Magical thinking is a bi-product of cognitive process that were useful in our evolutionary survival. We're so good at pattern matching that we see patterns everywhere, even when they don't exist. It's better to believe the movement in the dark is a tiger, rather than the wind blowing thru a bush. Its better to be wrong on that, than the other way around.

There's a compelling mission—both because of the enormous economic opportunity it represents, if it succeeds, and because of the broader impact it can have on the world. The mission is defined by a stubborn technical challenge. It has to be hard. No one wants to work on something that isn't difficult, and in a sense, choosing the hardest problems becomes a moat.

As far back as we know, humans have spent a lot of energy making what I call 'pointless, precious things.' Archaeologists recently uncovered a life-size sculpture of a bison, 14,000 years old, in a cave in France. That must have taken real effort by people likely living a Palaeolithic lifestyle. That's part of why we've been so dominant on this planet.

The sad reality is that if we tried to pass that declaration today, the UN General Assembly would fail to do so. Firstly, we don't have someone like Eleanor Roosevelt as an advocate for human rights, and where previously the US played a leadership role, Trump would no doubt block virtually every human rights pillar associated with the declaration.

In line with most highly-tuned talents, I absolutely believe that entrepreneurship is a genetic gift that you're born with. What you do with that gift depends on your upbringing, opportunities and inspirations; you either make them massively better or neglect them. That combination of genetics and sheer hard work is the 'secret' of getting to the top.

the overall picture that's emerging is that the controls which still work operate more along corporate boundaries than along national boundaries.

A lot of governments and corporations have made pledges to be carbon neutral by 2050 without having any way to do it. They don't know how to do it. They don't have the tools to do it. We have found over 1000 solutions that can help.