Endurance is mind over body. It's about tapping into something within us that allows us to push further than we ever thought possible, especially at our weakest moments.

Most great sellers and leaders figure out the things they love about their job – what they would do for free – and set up the infrastructure to intentionally avoid the parts that force them to show up inauthentically.

Your competitors are looking for the product, idea or feature that gives such a competitive advantage that they can take all your customers away from you. You need to work like someone's trying to take it all away from you, because they are.

If one wants to treat societal problems, then philanthropy and government spending are fine. If one wants to cure societal problems, one has got to come up with sustainable solutions- and that means attracting for-profit capital.

Art is necessary for the human mind. Art is about our dreams, fears, and imagination. Art is about everything outside of the system. It is a death sentence for art when it is within the system.

We're the mammal that likes Tabasco sauce! We're the only creature (as far as we know) that seeks out suffering and pain willingly. We do so not just through liberal splashes of Tabasco on our food, but also through seeking meaning through activities.

When considering the prevalence of this disease, we're speaking of 7 million diagnosed patients in the US. But how many Americans currently have the initial stages of Alzheimer's already festering in their brains? I concur with the higher estimates, suggesting around 40 million people.

This is a really exciting time for human space exploration, we have a lot to be hopeful about – and we have a whole bunch of private companies who have very credible strategies and vehicles. Like in so many other industries, the government has played a key role in kickstarting things – but to realise the full potential of this industry (space) we'll need private industry to get involved seriously; and we're just at the beginning of that journey.

Being able to trust is actually what makes us human. It's a very innate thing. And often, distrust and mistrust are learned behaviours that start to set in around the age of four.

In Silicon Valley there's a sense that there are 30 individuals who are 10x more capable than most people, it's like a power law scaling of talent... founders get immense leeway, capital rushes toward them... it also creates biases and situations where founders have more power than they should in their company.

If our future is to count as a utopia, we cannot allow a massive oppressed class of hyper-sentient, uncomfortable digital beings. We want it to be good for all kinds of minds.

To achieve greatness means to maximise your potential at the highest possible level, and the highest possible rate. I don't really consider myself the best, but the fact that people consider me the best I take as a great honour and as testament to the hard work and what I was able to achieve.