While people may have more connections than ever, these connections often lack depth; they are rarely reciprocal and seldom provide emotional sustenance. The pain of loneliness is something else entirely—stemming from being deliberately excluded, ostracized, or bullied.

Never was wealth the driver for me. – it was always hey, there's a cool idea here, let's make something of it. It was nice to be well rewarded, but the interesting part was working the problem, thinking about new things and how to bring them forward from being ideas to being products or new ways of doing things.

Entrepreneurs that do it for greed of money fail. Entrepreneurship isn't about greed, it has nothing to do with that; what matters is personal freedom.

We've found that innovation really happens when you constrain a problem very specifically and then throw it out to the world to solve. It's a slightly different way of thinking.

The rise of populism, backlash against globalisation, and movement against open borders means that populations support the weaponisation of economies even though it doesn't work to their own advantage.

In our modern world, everyone has an opinion about everything; and it's powerful to step back and go, 'you know what… I genuinely don't have an opinion about that…' – taking that position is seen as most terrible in today's day and age, but if you really work to dismantle all the things you think you are, you'll probably find you don't have an opinion about so many things.

Just being curious about yourself. You and I could read the same book on leadership or how to run a good team meeting, and we might take away the same five lessons, but we'd still apply them differently — even if we were trying to do exactly the same thing. That's because of our different personalities.

We are scientifically naked in front of this threat. We do not have the diagnostics to quickly detect an MDR or XDR case. Once detected, we do not have the drugs to effectively treat the patient at reasonable cost, and we do not have a TB vaccine.

Loneliness very much defines what this century has become. It's a feeling of being disconnected from our government, our fellow citizens and our employer. That feeling of being invisible, unseen and unheard occurs not just from those we are closest to but also from our workplace and state.

Invention has to be about the dream, there's an ingredient which you can't put in a business plan- it's intangible- but I saw it, it was there.

America has a class system, and it's becoming more rigid all the time. As inequality widens the damage spills over to children, and the ladder becomes so long that you have little hope of getting too far up it in your lifetime.

People think that life inside Silicon Valley firms is like life under an orange tree, where you suck on the oranges and everyone treats each other perfectly – but that's not quite right… people are ruthless, competitive… human.