There's an interesting over-representation of physicists within the existentialist community. Physicists, especially astronomers and cosmologists have had a glimpse of how vast the universe is, and the potential value of it, versus our planet.

The police never talk to us, they ignore us, they don't think we're human in this area.

Imagine you have to walk through a field that has a few land mines scattered through it. If you walk through it and nothing happens, it seems there is no danger. If you walk across it enough times, you'll step on a landmine. Traditional risk management simply fails to account for the fact that the most dangerous risks are those which occur infrequently and don't show up in track-records.

Ultimately, you have to fail at some stage with whatever you do, to get the successes that you need in the end.

There were large segments of the population with tremendous talent, who were being overlooked and underestimated because they didn't have the right 'pedigree.' – These individuals had fabulous business ideas and were genuinely going to change the world as they were solving real problems.

Winning is satisfaction. When you are working hard with your team, when you are working day and night, fighting hard, doing the best you can… when you make sacrifices and see things start to grow. That feeling of satisfaction is more important sometimes than money.

If we consider the United States, where potentially 40 million people could discover through brain imaging or blood tests that they have amyloid in their brains, the question arises: how can healthcare systems afford to provide a $100,000 per year therapy to so many people? It's simply not feasible.

My 90 seconds with Picabo changed my life. You'd be surprised how many kids have parents and peers around there who tell them they can't, I want to tell them they can.

You need to hire people who are smart, ideally smarter than you. There's a reason Google, Apple and their peers are filled with PhD's. The smarter your team (whether academically, or in experience) the more they will deliver.

Always remember – it's best to own 10% of a big number, than all of nothing!

In December 2020, we published in the journal nature that we could turn on 3 genes in mice, that are normally only switched on in embryos. By doing this, we could reverse the age of complex tissues in adult mice. We used this system to restore eyesight to blind, old, mice!

If you go into a new situation where you don't know anybody and you want to be more influential, don't look around the room and say hmmm… who can most help me here?… instead, look around and say hmmm…. Who can I most help here? You will put that person in a position where they will be standing on the balls of their feet to help you!