Alzheimer's starts its destructive process 30 years prior to its typical diagnosis. If we were to compare this to our approach with heart disease, it's like only making a diagnosis when a coronary bypass is needed.

Entrepreneurship is not for everybody, and it's also worth noting that you're not entitled to be a great entrepreneur. You're not entitled to be successful if you start a company, in fact the most likely outcome is that you won't be. Sometimes I meet founders and entrepreneurs who complain about how hard their fundraising or engineering challenges are… Guess what… yes…. It's really f***ing hard. That's the truth.

We believe that entrepreneurship is indispensable for the emergence of innovative companies that allow for the diversification and renewal of our economy, ensuring sustainable economic growth and the creation of qualified employment.

I'm 65 years old, and one of the things that amazes me is the number of people who work to get to a certain level of success in showbusiness, and then quit to go play golf?! There is nothing else I would want to do in this world.

I would suggest that most dollar problems are cyclical, and when the fed reserve raises interest rates, and the business cycle re-enters an upswing, there will be many reasons to buy dollar.

What the 1% of SMEs in a region that can really grow desperately need is local risk finance. We can think of this as venture capital. But we need venture capital that will work for SMEs, and that means it's got to be locally based. We've got a lot of venture capital, but it's nearly all in London and the Southeast.

We even regulate toy guns, by requiring orange tips — but lawmakers don't have the gumption to stand up to National Rifle Association extremists and regulate real guns as carefully as we do toys.

It's shocking how quickly this innovation [the internet] has become woven into the foundation of everything that we do. In just 30 years, the internet and the world wide web have gone from being generally unknown to consumers to being involved in every aspect of life, and necessary for almost everything. There is no healthy society without a healthy internet.

The process of problem definition is a discipline that we rarely teach or learn. It is one of the most important things that we can invest our time in. What are the true underlying causes of a problem? How are people really affected?

In general, 90% of people are overmedicating themselves with either drinking, smoking weed, whatever it is. People do not want to be uncomfortable, they cannot stand discomfort.

What happened was that people saw their place going down while London was booming. It's not countrywide; it's not that everyone in the country is poorer. London's doing fine. So people ask: why are they not doing fine when London's doing fine? They start to blame each other.

Most great sellers and leaders figure out the things they love about their job – what they would do for free – and set up the infrastructure to intentionally avoid the parts that force them to show up inauthentically.