The mythology tells us that you come to the valley and forge your own path, but in reality young people come here and are asked to essentially create careers that are a daisy chain of gigs on mini-innovation projects within large corporations.

Businesses have a tremendous amount of power to have impact through practices and business models that operate ethically, create useful goods and services, create jobs with dignity, and create opportunities in communities that may not have existed before.

We are facing a global catastrophe, one which should be a bigger motivator for us to come-together around a common cause than even World War II. Climate scientists tell us we're facing an existential crisis, and unless we get emissions under control in the next decade, that climate change will be irreversible.

I often tell students we work with that there will be moments when they, as newcomers, propose ideas or approaches that are innovative and correct simply because they bring a fresh perspective, uninfluenced by established norms or the supposed limits of what's possible.

People have regarded as a paradox- the fact that Newton spent most of his time doing alchemy, which doesn't sound very scientific, and only part of his time doing mechanics and gravitation. Of course, his discoveries in mechanics and his law of gravitation were absolutely foundational to all of quantitative science, engineering, technology and, indeed, everything that came after

Bystander effect isn't necessarily due to a lack of willingness or ability to make a difference. Rather, the real challenge stems from feeling overwhelmed by the sheer magnitude of the issues we're passionate about. They're vast, and against them, we often feel insignificant.

At some point, if this kind of technological progress continues, it would seem that our descendants will become entirely digital: uploads or artificial intellects implemented on computers.

If technology is just for the privileged few, then it will concentrate power in the hands of those who already have it.

Hope is active — it's a discipline. It would be such a profound disservice to give up: a disservice to young people, to the scientists who have spent decades working. There is no other option but to be hopeful. That is what activates me. There is simply no other option.

At Colossal, we are not going to work in humans or non-human primates because we felt like we're already going to have an uphill battle with transparency and education, and we don't want people to be like, if a hair-loss treatment comes out of Colossal, 'are they selling a gene from a woolly mammoth?'

Winning is good, losing is bad! If you're winning, you can give back — to your family, institutions of your choice, and your local communities. If you're losing, your pockets are empty.

Fundamental sense of well-being crucially depends on our having the ability to exert control over our environment and recognising that we do.