“The first thing I'd say is to quote an old saying by William Goldman which is, 'in this business, nobody knows anything' – otherwise it would be sure fire and completely fail-safe!”
— James Clayton

The quote archive

Wisdom in fragments

A growing archive of 3,000+ moments, drawn from every interview.

The brain's adaptability is astounding. The brain is continuously rewiring; it's different now than it was just 30 seconds ago. That is fascinating and offers great promise.

— Rebecca Heiss

The stress response is designed for '3 minutes of screaming terror across the Savannah.' If you're not experiencing such an intense moment, it's likely that your stress response isn't calibrated right. In our digital age, it might lead to an inadvertent 'reply all' or perhaps a hastily written email.

— Rebecca Heiss

One major overhead entrepreneurial business often grapple with is the exorbitant rent in cities. Moving to a smaller town offers a significant reduction in these costs and promotes regional economic balance.

— Sridhar Vembu

Founder and CEO of Zoho Corporation, cloud computing company

When you invest in training individuals, they often become more devoted to your organization. It's almost like a karmic cycle - creating a virtuous cycle of growth and loyalty.

— Sridhar Vembu

Founder and CEO of Zoho Corporation, cloud computing company

Think of bootstrapping like a multi-stage booster rocket, where each stage propels and prepares you for the next, and the momentum continues building.

— Sridhar Vembu

Founder and CEO of Zoho Corporation, cloud computing company

Choosing not to rely on outside funding offers greater freedom overall. While there's significant sacrifice upfront, about 10 years down the line, you begin to truly value the autonomy it provides.

— Sridhar Vembu

Founder and CEO of Zoho Corporation, cloud computing company

If I was selling research, why not genuinely sell something in the business world? I realized that entrepreneurship might be the key to growth and economic solutions.

— Sridhar Vembu

Founder and CEO of Zoho Corporation, cloud computing company

Historically, we've viewed the human mind as the paramount problem solver. Yet, is it still our ally, or has it become our adversary? I believe we're at a juncture where the human mind is shifting towards the latter.

— Bryan Johnson

Biohacker & Blueprint Project Founder focused on extreme longevity optimization

The act of humans making choices will become a mere memory. We'll be spectators in a novel arena. But is this the zenith of liberty or just a cage?

— Bryan Johnson

Biohacker & Blueprint Project Founder focused on extreme longevity optimization

Algorithms understand and can guide me better than I can guide myself. The real game-changer is data. I'm willing to yield control to an algorithm that proves to be superior.

— Bryan Johnson

Biohacker & Blueprint Project Founder focused on extreme longevity optimization

For the first time as a species, we're truly in the dark about what's around the corner. In the past, the human brain could synthesize information and anticipate the future. But now, in an era where computational intelligence dominates innovation, no human can accurately forecast what lies ahead.

— Bryan Johnson

Biohacker & Blueprint Project Founder focused on extreme longevity optimization

In the tech sphere, when you acquire a company, you're seldom buying the present product. Instead, you're investing in their future innovations. This means retaining talent is paramount.

— John Chambers

Former CEO of Cisco Systems, led company through internet boom era

I start by asking: How will our customers benefit from this acquisition? I tend to shy away from companies that don't share a similar cultural ethos. Even if an acquisition seems financially sound, if there's a stark cultural mismatch, I'd usually reconsider.

— John Chambers

Former CEO of Cisco Systems, led company through internet boom era

You move faster with replication. There was a time I could finalize an acquisition of a $3 billion company within days, from hearing about it on a Thursday to announcing it publicly on a Sunday. Such speed is a testament to the value of a replicable process.

— John Chambers

Former CEO of Cisco Systems, led company through internet boom era

I urge everyone to channel their inner teenager. Think back to those fearless days brimming with creativity and ambition. As we age, societal rewards for 'playing it safe' can stifle our innovative spirit.

— John Chambers

Former CEO of Cisco Systems, led company through internet boom era

I firmly advocate the idea of reinventing oneself every 5 years.

— John Chambers

Former CEO of Cisco Systems, led company through internet boom era