It's not success we should be seeking but consonance, alignment, flow. When what we do actually matters to us. We are being called upon to solve a problem at hand, to use what we do best in the world, and in turn being rewarded for in a way that is meaningful to us.

Entrepreneurship means the unrelenting belief that there has to be a better way. There has to be a better way of doing things... If it was obvious that things were already being done in a great way that couldn't be improved? There wouldn't be any need for entrepreneurs to step-in and create new ways of doing things that don't rely on the baggage of the past.

Every business makes money as a secondary purpose. It's the coincidental result of creating customer value and changing the world in some way that people are willing to pay for and find valuable. That is the primary activity of a business – and you happen to get paid for it.

I came away from space flight realising that I don't have enough faith to be an atheist. Life is so amazing. Even the simplest organisms have millions of cells that have to randomly align in a perfect way, and those processes are infinitesimally less complex than emotions and consciousness. When you look at the universe and the forces of nature – science has to explain how it all works, but to my mind, there just has to be a creator.

He approached me, asking what he should do, to which I responded, 'You're the boss. Why are you asking me?' My conviction has always been that it's crucial to operate this business as an institution; I don't have to always be glued to my chair.

Early stage investing is very difficult and financially risky meaning that a lot of what we invest in won't work. A lot of what we do is, in effect, pilots to see if individual projects or funds can generate some positive return.

Instead of militaries fighting militaries, we now have militaries or military motivated agents that are able to activate civilians in each other's countries. Social media is global national security threat, and one that we're not even spending billions of dollars to protect against.

AI has been an area of technology for many decades, but the advances of the past five-years show us why this is one of the major technology events of the last several centuries.

Operating on less than six hours of sleep, your immune system may function at merely 40 to 50% of its full potential. This is why individuals who suffer from poor sleep quality, including those with sleep apnoea, exhibit a higher incidence of cancer and Alzheimer's disease.

What's going to happen is that you just get busier and busier and move faster and faster! We treat productivity tools as if they're going to lead to our salvation, they're absolutely not going to.

I urge everyone to channel their inner teenager. Think back to those fearless days brimming with creativity and ambition. As we age, societal rewards for 'playing it safe' can stifle our innovative spirit.

If morality is the science of the good, ethics is the study of that science, and bioethics is the study of that science as it relates to biosphere.