We characterise our ideal 'Substacker' in affectionate terms – we call them outsider nerds – they're outsiders insofar as they don't fit comfortably in the dominant media structure for whatever reason – perhaps they feel they can do better work outside of it They're nerds insofar as they're especially knowledgeable or passionate about a particular subject area.

The power of regret is that it clarifies what we value and instructs on how to do better. When people tell you what they regret they most, they are telling you what they value the most.

I've been doing this a long time and have very rarely seen a company with sustainable competitive advantage like Amazon has. They have a very low cost of capital, they are very efficient, and the government provide an additional advantage in that the transactions are not tax.

We got to the point where, we are not on our grandparents' planet anymore. Meat has become less healthy for us – it's too available. There are too many calories, too much saturated fat. Animals are no longer 'free-rangy', they are growing in very tight confined conditions.

We are facing the mother of all debt crises. When you look at the data on private and public debt, the debt to GDP ratio was near 200% of global GDP in 1999, today it's more like 350% and rising. In advanced economies, it's over 420% and in China, 330% and rising.

In my lab, we can control ageing easily. We have mice where we can dial up the ageing process or reverse it. It's not that hard when you know how. Until recently, we didn't know there was a backup copy of the information which has been corrupted, and now we can reset it using an embryonic gene trick. Ultimately, I think we'll be able to pop a pill and reset our body's age.

I'm genuinely convinced that the upcoming decade will be the era of India as a product nation. The product revolution has begun, what we're terming as 'India SaaS' – the development of global SaaS products originating in India, not merely for the Indian market, but for the world.

Despite my anxiety and the constraints that sometimes hold us back, acting connects us to something larger. It's a business, sure, but there's a steep thrill in the moments of performance. The thrill of feeling truly alive, of connecting deeply with someone else, even in imaginary circumstances. That thrill of creation is my guiding star.

More than just being a luxury item, they are pieces that represent milestone moments- that's why they're important. People also reflect on whether diamonds are a hard asset class. They are the hardest of all assets, being the hardest asset known to man!

…discrimination on the basis of sex, it has been said, is the last universally accepted form of discrimination, practiced without secrecy or pretence even in those liberal circles that have long prided themselves on their freedom from prejudice against racial minorities.

Confidence, after all, is simply one's belief in their own ability to accomplish a task or achieve a result. It's an elusive and abstract feeling. In my experience, many of the individuals I work with, including Olympians, often lack this so-called essential trait. My approach is always to redirect their focus from this nebulous concept of confidence to the concrete tasks at hand.

Resilience is not a muscle we're born with, it's something we have to build and believe in over time. We should never ask ourselves how much resilience we have, but rather how much we can build, and how we can build it into ourselves, our friends, and the people around us.