I hope that the totality of what I've done, or that which Freada and I have done together, really gives people a sense of hope and possibility, in a practical way, that business can be a constructive force in the world and genuinely help make the world a better place for everyone.

Surveys show that, surprisingly, more people fear Alzheimer's disease more than they do cancer. This is due to the fact that Alzheimer's isn't a quick affliction; it extends over a period of 8-20 years, during which individuals slowly lose themselves. This disease methodically dismantles your neural network, a network that represents a tapestry of experiences and connections you've built throughout your life.

So far from being a separate evolutionary lineage with deep roots, we humans were in fact embedded within the great ape family. Humans are now, strictly speaking, firmly ensconced within the chimpanzee family.

You have to understand, for instance, that in my lifetime until I was fifty or so- I had not witnessed any period without inflation of twenty or thirty percent, and sometimes one hundred percent.

If you're managing that way in the age of outrage, basically you're saying your organization will be in constant firefighting mode. That's unsustainable. The organization will very quickly wither and die.

The stress response is designed for '3 minutes of screaming terror across the Savannah.' If you're not experiencing such an intense moment, it's likely that your stress response isn't calibrated right. In our digital age, it might lead to an inadvertent 'reply all' or perhaps a hastily written email.

Anyone who takes the DMT space seriously is forced to live a kind of parallel life. You slip back into 'normal life mode' and almost have to ignore the implications of what you saw. It shows you that this tawdry, flimsy domain we think is foundational to reality is actually nothing more than a theatre screen.

Aging is a side-effect of being a machine with moving parts. All such machines, whether living or not, inherently create entropy in their structure. Living organisms have immensely sophisticated systems for exporting that entropy, but those systems are generally not 100% comprehensive, so aging still happens.

I don't want my success to define me. I want people to see me without all that – success comes and goes, without it, I am still who I am.

One is: Do I trust you with my feelings? Do I think that you're going to be a listener who is non-judgmental, or do I think you're going to judge me—'Marc is weak because he's anxious,' or 'Marc is a man and he's feeling sad; dudes don't feel sad.' So if I think you're going to judge me for my feelings, I'm going to be much more guarded about whether or not I express them.

more Americans died in gun homicides and suicides in six months than have died in the last 25 years in every terrorist attack and the wars in Afghanistan and Iraq combined…

In a world where everyone gets to play in social media, we're about to realise that the vast majority of people aren't good enough. We've never had to quantify this before because there were people in-place to filter the people America got to see, and most were qualified to some level. Now we have an ecosystem where everyone gets out there and says they're great. The vast majority are not going to be great at what they pontificate to be great at, and we're going to watch them fail right in front of our eyes.